Cover Page

Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food

 

 

Edited by Jack F. Kay, James D. MacNeil, and Jian Wang

 

 

 

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WILEY SERIES ON MASS SPECTROMETRY

Series Editors

Dominic M. Desiderio

Departments of Neurology and Biochemistry
University of Tennessee Health Science Center

Joseph A. Loo

Department of Chemistry and Biochemistry UCLA

Founding Editors

Nico M. M. Nibbering (1938–2014)

Dominic M. Desiderio

A complete list of the titles in this series appears at the end of this volume.

Dedication

This book is dedicated to the memory of Dr. John J. O'Rangers Jr., 11 June 1936–20 January 2013.

John was internationally well known and respected in the field of veterinary drug residue chemistry and international regulations. Both Dr. James MacNeil and Dr. Jack Kay were honored to have known and worked with him over many years and also to call him a friend. Developing international cooperation and understanding was a cornerstone of John's view of life and work ethic, regardless of the more politically opinionated views held by some. Many international developments in this field and friendships are the result of the work John conducted behind the scenes to break down barriers. He truly was one of a kind and his passing leaves us all impoverished.

Preface

Food safety continues to be a topic of great interest to consumers and is frequently a topic for media discussion. However, what is not routinely reported is the vast effort by many national, regional, and international bodies and scientists – both governmental and independent – to ensure that food production and trade do not place consumers at risk while ensuring a continuous supply of wholesome food.

A key aim of regulating the use of veterinary drugs is to ensure that authorized products are used responsibly in animals and that their residues in food of animal origin do not pose unacceptable health risks to consumers. To assist in this process, robust and validated analytical methods to detect a wide range of potential residues in food matrices are required.

The earlier volume in this series, Chemical Analysis of Antibiotic Residues in Food, was published in 2012 and set out in detail how drug safety is considered and limits are set for their residues in foods. It also described how residue monitoring programs are established and checked to ensure sound results are generated to inform necessary regulatory actions to protect consumers. These topics are generic and apply equally to antibiotics and other veterinary drug classes. The companion volume to this current book also provided detailed information on analytical methods for antibiotic residues.

The purpose of this current book, Chemical Analysis of Non-antimicrobial Veterinary Drug Residues, is to update readers on developments in technology and approaches since the publication of the earlier volume. It also seeks to expand the coverage of veterinary drug residues to all other key areas of veterinary drug treatments, thus providing a comprehensive two-volume set for reference and training purposes.

The main themes of the book include detailed discussions on emerging technologies (Chapter 2); high resolution mass spectrometry and related techniques (Chapter 3); hormones and β-agonists (Chapter 4); anthelmintics (Chapter 5); sedatives and tranquilizers (Chapter 6); pyrethroids, carbamates, organophosphates, and other pesticides used in veterinary medicines (Chapter 7); non-steroidal anti-inflammatories (Chapter 8); dyes (Chapter 9); and developments in the validation of multi-class multi-residue methods and related quality control/quality assurance issues (Chapter 10).

The editors and authors of this book are internationally recognized experts and leading scientists with extensive personal experience in preparing food safety regulations and/or in the chemical analyses of veterinary drug residues in food of animal origin. This book offers a valuable and up to date view of the science in this area. It has been deliberately written and organized to complement and update where necessary the information contained in the earlier companion volume. The editors hope that this volume completes and addresses the need for readers from regulatory backgrounds and analytical laboratory staff to have a cutting-edge reference and training resource for the residues of all veterinary drug residues in food of animal origin.

26 August, 2016

Jack F. Kay
University of Strathclyde,
Glasgow, Scotland

James D. MacNeil
St. Mary's University,
Halifax, Canada

Jian Wang
Canadian Food Inspection Agency,
Calgary, Canada

List of Contributors

Christine Akre

Saskatoon Laboratory

Canadian Food Inspection Agency

Saskatoon, Saskatchewan

Canada

Wendy C. Andersen

Animal Drugs Research Center

US Food and Drug Administration

Denver, Colorado

USA

Marco H. Blokland

RIKILT

Part of Wageningen UR

Wageningen

The Netherlands

Joe O. Boison

Saskatoon Laboratory

Canadian Food Inspection Agency

Saskatoon, Saskatchewan

Canada

Toine Bovee

RIKILT

Part of Wageningen UR

Wageningen

The Netherlands

Andrew Cannavan

Food and Environmental Protection Laboratory

Joint FAO/IAEA Division on Nuclear Techniques in Food and Agriculture

International Atomic Energy Agency

Vienna

Austria

Vesna Cerkvenik-Flajs

Veterinary Faculty

Department of Pathology and Administrative Veterinary Medicine

Laboratory for Ecotoxicology and Forensic Veterinary Medicine

University of Ljubljana

Ljubljana

Slovenia

Alan Chicoine

Department of Veterinary Biomedical Sciences

Western College of Veterinary Medicine

University of Saskatchewan

Saskatoon, Saskatchewan

Canada

Martin Danaher

Food Safety Department

Teagasc Food Research Centre

Ashtown

Dublin 15

Ireland

Ambrose Furey

Department of Chemistry

Cork Institute of Technology (CIT)

Bishopstown

Cork

Ireland

Zora Jandrić

Food and Environmental Protection Laboratory

Joint FAO/IAEA Division on Nuclear Techniques in Food and Agriculture

International Atomic Energy Agency

Vienna

Austria

Anton Kaufmann

Official Food Control Authority of the Canton of Zürich

Fehrenstrasse

Zürich

Switzerland

Jack F. Kay

Department of Mathematics & Statistics

University of Strathclyde

Glasgow, Scotland

United Kingdom

Jack J. Lohne

Animal Drugs Research Center

US Food and Drug Administration

Denver, Colorado

USA

James D. MacNeil

Department of Chemistry

St Mary's University

Halifax, Nova Scotia

Canada

Jelka Pleadin

Laboratory for Analytical Chemistry

Croatian Veterinary Institute

Zagreb

Croatia

Fernando Ramos

Pharmacy Faculty

Coimbra University

Coimbra

Portugal

Nathalie G.E. Smits

RIKILT

Part of Wageningen UR

Wageningen

The Netherlands

Saskia S. Sterk

RIKILT

Part of Wageningen UR

Wageningen

The Netherlands

Philip Teale

LGC Ltd

Fordham

Cambridgeshire

UK

Sarah Tuck

Food Safety Department

Teagasc Food Research Centre

Dublin 15

Ireland

Sherri B. Turnipseed

Animal Drugs Research Center

US Food and Drug Administration

Denver, Colorado

USA

Leendert A. van Ginkel

RIKILT

Part of Wageningen UR

Wageningen

The Netherlands

Eric Verdon

Laboratory of Fougères

EU Reference Laboratory for Antimicrobial and Dye Residues in Food French Agency for Food Environmental and Occupational Health Safety

Fougères

France

Ana Vulić

Laboratory for Analytical Chemistry

Croatian Veterinary Institute

Zagreb

Croatia

About the Editors

Dr. Jack F. Kay received his Ph.D. from the University of Strathclyde, Glasgow, Scotland in 1980 and has been involved with veterinary drug residue analyses since 1991. He worked for the UK Veterinary Medicines Directorate to provide scientific advice on residue monitoring programs and managed the R&D program until his early retirement in September 2014. He helped draft Commission Decision 2002/657/EC and is an ISO trained assessor for audits to ISO 17025. He was co-chair of the CCRVDF ad hoc Working Group on Methods of Sampling and Analysis and steered Codex Guideline CAC/GL 71-2009 to completion after Dr. MacNeil retired. He co-chaired work extending this to cover multi-residue method performance criteria. He assisted JECFA in preparing an initial consideration of setting MRLs in honey and then took this forward for the CCRVDF. He also holds an Honorary Senior Research Fellowship in the Department of Mathematics and Statistics at the University of Strathclyde.

Dr. James D. MacNeil received his Ph.D. from Dalhousie University, Halifax, NS, Canada in 1972 and worked as a government scientist until his retirement in 2007. From 1982 to 2007 he was Head, Centre for Veterinary Drug Residues, now part of the Canadian Food Inspection Agency. He has served as a member of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), co-chair of the working group on methods of Analysis and Sampling, Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF), is the former scientific editor for “Drugs, Cosmetics & Forensics” of J. AOAC Int., worked on IUPAC projects, has participated in various consultations on method validation, and is the author of numerous publications on veterinary drug residue analysis. He is a former General Referee for methods for veterinary drug residues for AOAC International and was appointed scientist emeritus by CFIA in 2008. He holds an appointment as an adjunct professor in the Department of Chemistry, St. Mary's University, Halifax, Canada, and has served as a part-time consultant to the JECFA Secretariat of the Food and Agriculture Organization of the United Nations since 2012.

Dr. Jian Wang received his Ph.D. at the University of Alberta in Canada in 2000, and then worked as a Postdoctoral Fellow at the Agriculture and Agri-Food Canada in 2001. He has been working as a leading research scientist at the Calgary Laboratory with the Canadian Food Inspection Agency since 2002. His scientific focus is on method development and validation using LC-MS/MS, UHPLC-QTOF, and UHPLC-Q Orbitrap for analyses of chemical residues including antibiotics, pesticides, and other chemical contaminants in foods. He also develops statistical approaches to estimating the measurement uncertainty based on method validation and quality control data using SAS program.