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Edition History

1e 1980, Blackwell Publishing; 2e 1984 - Blackwell Publishing; 3e 1993, Blackwell Publishing; 4e 2001, Blackwell Publishing; 5e 2006, Blackwell Publishing; 6e 2011, Wiley-Blackwell; 7e 2015, Wiley-Blackwell

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Library of Congress Cataloging-in-Publication Data

Names: Hoffbrand, A. V., author. | Steensma, David P., author.

Title: Hoffbrand's essential haematology / Allan Victor Hoffbrand, David Peter Steensma.

Other titles: Essential haematology

Description: Eighth edition. | Hoboken : Wiley, 2019. | Revision of: Essential haematology / A.V.
Hoffbrand, P.A.H. Moss, J.E. Pettit. 2011.

6th ed.

Identifiers: LCCN 2019026455 (print) | LCCN 2019026456 (ebook) | ISBN 9781119495901
(paperback) | ISBN 9781119495925 (adobe pdf) | ISBN 9781119495956 (epub)

Subjects: LCSH: Blood—Diseases. | Hematology.

Classification: LCC RC633 .H627 2019 (print) | LCC RC633 (ebook) | DDC 616.1/5—dc23

LC record available at https://lccn.loc.gov/2019026455

LC ebook record available at https://lccn.loc.gov/2019026456

Cover image: © DENNIS KUNKEL MICROSCOPY/science source. Human red blood cells, activated platelets, T lymphocyte (turquoise) and granulocytes (green), coloured scanning electron micrograph (SEM). Magnification: x1000 when shortest axis printed at 25 millimetres.

Cover design by Wiley

CONTENTS

Cover

Preface to the Eighth Edition

Preface to the First Edition

How to use your textbook

About the companion website

Chapter 1 Haemopoiesis

Key topics
Site of haemopoiesis
Haemopoietic stem and progenitor cells
Bone marrow stroma
The regulation of haemopoiesis
Haemopoietic growth factors
Growth factor receptors and signal transduction
Adhesion molecules
The cell cycle
Transcription factors
Epigenetics
Apoptosis
Summary

Chapter 2 Erythropoiesis and general aspects of anaemia

Key topics
Blood cells
Erythropoietin
Haemoglobin
The red cell
Anaemia
Ineffective erythropoiesis
Summary

Chapter 3 Hypochromic anaemias

Key topics
Nutritional and metabolic aspects of iron
Iron deficiency
Anaemia of chronic disorders
Iron refractory iron deficiency anaemia (IRIDA)
Sideroblastic anaemia
Lead poisoning
Differential diagnosis of hypochromic anaemia
Summary

Chapter 4 Iron overload

Key topics
Assessment of iron status and organ function
Hereditary (genetic, primary) haemochromatosis
Transfusional iron overload
Iron chelation therapy
Summary

Chapter 5 Megaloblastic anaemias and other macrocytic anaemias

Key topics
Introduction to macrocytic anaemia
Megaloblastic anaemias
Vitamin B₁₂ (B₁₂, cobalamin)
Folate
Causes of severe vitamin B₁₂ deficiency
Causes of mild vitamin B₁₂ deficiency
Folate deficiency
Clinical features of megaloblastic anaemia
Diagnosis of vitamin B₁₂ or folate deficiency
Treatment
Other megaloblastic anaemias
Other macrocytic anaemias
Summary

Chapter 6 Haemolytic anaemias

Key topics
Normal red cell destruction
Introduction to haemolytic anaemias
Intravascular and extravascular haemolysis
Hereditary haemolytic anaemias
Acquired haemolytic anaemias
Summary

Chapter 7 Genetic disorders of haemoglobin

Key topics
Haemoglobin synthesis during human development
Haemoglobin abnormalities
Thalassaemias
Sickle cell disease
Prenatal diagnosis of genetic haemoglobin disorders
Summary

Chapter 8 The white cells, part 1: granulocytes, monocytes and their benign disorders

Key topics
Granulocytes
Granulopoiesis
Clinical applications of G-CSF
Monocytes
Disorders of neutrophil and monocyte function
Causes of neutrophil leucocytosis
Neutropenia
Causes of monocytosis, eosinophil and basophil leucocytosis
Histiocytic and dendritic cell disorders
Lysosomal storage diseases
Summary

Chapter 9 The white cells, part 2: lymphocytes and their benign disorders

Key topics
Lymphocytes
Immunoglobulins
Antigen–receptor gene rearrangements
Complement
The immune response
Lymphocytosis
Immunodeficiency
Differential diagnosis of lymphadenopathy
Summary

Chapter 10 The spleen

Key topics
The anatomy and circulation of the spleen
The functions of the spleen
Extramedullary haemopoiesis
Imaging the spleen
Splenomegaly
Hypersplenism
Hyposplenism
Splenectomy
Prevention of infection in hyposplenic patients
Summary

Chapter 11 The aetiology and genetics of haematological neoplasia

Key topics
The incidence of haematological neoplasms
The aetiology of haemopoietic neoplasia
The genetics of haemopoietic neoplasia
Chromosome nomenclature
Specific examples of genetic abnormalities in haematological neoplasms
Diagnostic methods used to study neoplastic haemopoietic cells
Value of genetic markers in management of haematological neoplasia
Summary

Chapter 12 Management of haematological malignancy

Key topics
General supportive therapy
Chimeric antigen receptor (CAR)-T cells
Summary

Chapter 13 Acute myeloid leukaemia

Key topics
Classification of leukaemia
Diagnosis of acute leukaemia
Acute myeloid leukaemia (AML)
Summary

Chapter 14 Chronic myeloid leukaemia

Key topics
Chronic myeloid leukaemia
Summary

Chapter 15 Myeloproliferative neoplasms

Key topics
Genetic drivers of myeloproliferation
Polycythaemia
Primary polycythaemia (erythrocytosis): polycythaemia vera (PV)
Secondary polycythaemia
Apparent polycythaemia
Essential thrombocythaemia
Primary myelofibrosis
Mastocytosis
Chronic neutrophilic leukaemia
Chronic eosinophilic leukaemia
Summary

Chapter 16 Myelodysplastic syndromes

Key topics
Myelodysplastic syndromes (MDS)
Clonal haemopoiesis of indeterminate potential (CHIP)
Myelodysplastic syndromes/myeloproliferative ‘overlap’ neoplasms
Summary

Chapter 17 Acute lymphoblastic leukaemia

Key topics
Incidence and pathogenesis
Classification
Clinical features
Investigations
Cytogenetics and molecular genetics
Treatment
Prognosis
Summary

Chapter 18 The chronic lymphocytic leukaemias

Key topics
Diagnosis
B-cell diseases
T-cell diseases
Summary

Chapter 19 Hodgkin lymphoma

Key topics
History and pathogenesis
Clinical features
Haematological and biochemical findings
Diagnosis and histological classification
Clinical staging
Treatment
Prognosis
The late effects of Hodgkin lymphoma and its treatment
Summary

Chapter 20 Non-Hodgkin lymphomas

Key topics
Introduction to non-Hodgkin lymphomas
Clinical features of NHL
Specific subtypes of non-Hodgkin lymphoma
T-cell lymphomas
Summary

Chapter 21 Multiple myeloma and related plasma cell neoplasms

Key topics
Paraproteinaemia
Multiple myeloma
Other plasma cell neoplasms
Monoclonal gammopathy of undetermined significance
Amyloidosis
Hyperviscosity syndrome
Summary

Chapter 22 Aplastic anaemia and bone marrow failure

Key topics
Pancytopenia
Aplastic anaemia
Paroxysmal nocturnal haemoglobinuria
Red cell aplasia
Congenital dyserythropoietic anaemias
Osteopetrosis
Summary

Chapter 23 Haemopoietic stem cell transplantation

Key topics
Principles of stem cell transplantation
Autologous stem cell transplantation
Summary

Chapter 24 Platelets, blood coagulation and haemostasis

Key topics
Platelets
Blood coagulation
Endothelial cells
Haemostatic response (Fig. 24.1)
Fibrinolysis
Tests of haemostatic function
Summary

Chapter 25 Bleeding disorders caused by vascular and platelet abnormalities

Key topics
Abnormal bleeding
Vascular bleeding disorders
Thrombocytopenia
Disorders of platelet function
Diagnosis of platelet disorders
Treatment of thrombocytopenia and platelet disorders
Summary

Chapter 26 Coagulation disorders

Key topics
Hereditary coagulation disorders
Acquired coagulation disorders
Thromboelastography: near-patient (point-of-care) testing
Summary

Chapter 27 Thrombosis 1: pathogenesis and diagnosis

Key topics
Arterial thrombosis
Venous thrombosis
Investigation of thrombophilia
Diagnosis of venous thrombosis
Summary

Chapter 28 Thrombosis 2: treatment

Key topics
Treatment overview
Parenteral anticoagulants
Heparin
Oral anticoagulants
Mechanical methods of prophylaxis of DVT and PE
Fibrinolytic drugs
Antiplatelet drugs
Summary

Chapter 29 Haematological changes in systemic diseases

Key topics
Anaemia of chronic disorders
Haematological problems in the elderly
Malignant disease (other than primary bone marrow disease)
Rheumatoid arthritis (and other connective tissue disorders)
Renal failure
Congestive heart failure
Liver disease
Hypothyroidism
Infections
Non-specific monitoring of systemic disease
Summary

Chapter 30 Blood transfusion

Key topics
Blood donor selection
Red cell antigens and blood group antibodies
Hazards of allogeneic blood transfusion
Techniques in blood group serology
Cross-matching and pre-transfusion tests
Complications of blood transfusion
Reduction of blood product use
Blood components
Preparations from human plasma
Acute blood loss and massive haemorrhage
Summary

Chapter 31 Pregnancy and neonatal haematology

Key topics
Haematology of pregnancy
Neonatal haematology
Haemolytic disease of the newborn
Summary

Appendix

Index

End User License Agreement

List of Tables

Chapter 1

Table 1.1
Table 1.2
Table 1.3

Chapter 2

Table 2.1
Table 2.2
Table 2.3
Table 2.4
Table 2.5
Table 2.6
Table 2.7

Chapter 3

Table 3.1
Table 3.2
Table 3.3
Table 3.4
Table 3.5
Table 3.6
Table 3.7
Table 3.8
Table 3.9

Chapter 4

Table 4.1
Table 4.2
Table 4.3
Table 4.4

Chapter 5

Table 5.1
Table 5.2
Table 5.3
Table 5.4
Table 5.5
Table 5.6
Table 5.7
Table 5.8
Table 5.9
Table 5.10

Chapter 6

Table 6.1
Table 6.2
Table 6.3
Table 6.4
Table 6.5
Table 6.6

Chapter 7

Table 7.1
Table 7.2
Table 7.3

Chapter 8

Table 8.1
Table 8.2
Table 8.3
Table 8.4
Table 8.5
Table 8.6
Table 8.7

Chapter 9

Table 9.1
Table 9.2
Table 9.3
Table 9.4

Chapter 10

Table 10.1
Table 10.2
Table 10.3
Table 10.4

Chapter 11

Table 11.1
Table 11.2

Chapter 12

Table 12.1
Table 12.2

Chapter 13

Table 13.1
Table 13.2
Table 13.3
Table 13.4
Table 13.5

Chapter 14

Table 14.1
Table 14.2
Table 14.3

Chapter 15

Table 15.1
Table 15.2
Table 15.3
Table 15.4
Table 15.5
Table 15.6
Table 15.7
Table 15.8

Chapter 16

Table 16.1
Table 16.2
Table 16.3
Table 16.4
Table 16.5

Chapter 17

Table 17.1
Table 17.2
Table 17.3
Table 17.4

Chapter 18

Table 18.1
Table 18.2
Table 18.3
Table 18.4
Table 18.5

Chapter 19

Table 19.1
Table 19.2
Table 19.3

Chapter 20

Table 20.1
Table 20.2
Table 20.3
Table 20.4
Table 20.5

Chapter 21

Table 21.1
Table 21.2
Table 21.3
Table 21.4
Table 21.5
Table 21.6

Chapter 22

Table 22.1
Table 22.2
Table 22.3

Chapter 23

Table 23.1
Table 23.2
Table 23.3
Table 23.4
Table 23.5

Chapter 24

Table 24.1
Table 24.2
Table 24.3

Chapter 25

Table 25.1
Table 25.2
Table 25.3
Table 25.4

Chapter 26

Table 26.1
Table 26.2
Table 26.3
Table 26.4
Table 26.5
Table 26.6
Table 26.7

Chapter 27

Table 27.1
Table 27.2
Table 27.3
Table 27.4

Chapter 28

Table 28.1
Table 28.2
Table 28.3
Table 28.4
Table 28.5
Table 28.6
Table 28.7
Table 28.8

Chapter 29

Table 29.1
Table 29.2
Table 29.3
Table 29.4
Table 29.5
Table 29.6

Chapter 30

Table 30.1
Table 30.2
Table 30.3
Table 30.4
Table 30.5
Table 30.6
Table 30.7
Table 30.8
Table 30.9
Table 30.10

Chapter 31

Table 31.1
Table 31.2

List of Illustrations